期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 227, 期 1-2, 页码 44-51出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.06.005
关键词
Muscular dystrophy; Mdx; Acetylcholine receptor; Cytokine; Macrophage; Skeletal muscle
资金
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- FOPESQ-UFF
- FAPERJ (Fundacao de Amparo a Pesquisa do Rio de Janeiro)
Mdx mice develop an inflammatory myopathy characterized at different ages by myonecrosis with scattered inflammatory infiltrates followed by muscular regeneration and later persistent fibrosis. This work aimed to verify the putative anti-inflammatory role of nicotinic acetylcholine receptor (nAChR) in the mdx muscular lesion. Mitigation of myonecrosis and decreased TNF alpha production were accompanied by increased numbers of F4/80 macrophages expressing nAChR alpha 7. In vivo treatment with nicotine attenuated muscular inflammation characterized by reduced metalloprotease MMP-9 activity, TNF alpha and NFkB content and increased muscular regeneration. Our data indicate that nAChR activation influences local inflammatory responses in the muscular lesion of mdx mice. (c) 2010 Elsevier B.V. All rights reserved.
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