期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 226, 期 1-2, 页码 192-193出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.06.016
关键词
Multiple sclerosis; B lymphocytes; Antibody gene rearrangement; Somatic hypermutation; CNS tissue
资金
- National Multiple Sclerosis Society [RG3267, RG2172, RG3308]
- National Institute of Health [N01A140041, U01DK6192601, R01NS024247, P01 AI39671, P01NS38037]
- FISM - Fondazione Italiana Sclerosi Multipla [2008/B/3]
- National Health and Medical Research Council of Australia
- National Multiple Sclerosis Society
B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF. (C) 2010 Elsevier B.V. All rights reserved.
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