Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke

We defined whether resveratrol administration during the acute phase of ischemic stroke reduces brain injury in mice. Infarct volumes were decreased significantly in both sexes with different doses of resveratrol (5 mg/kg for males and 1 mg/kg for females) administered 3 h after ischemic stroke. Administration of resveratrol 6 h after insult was also effective to decrease infarct volumes. Resveratrol suppressed expressions of IL-1 beta and TNF-alpha, microglial activation, and ROS production in the ischemic cortex. The findings suggest that the suppression of inflammation is partly associated with the neuroprotective effects of resveratrol, and resveratrol can be developed as a therapeutic drug for acute ischemic stroke. (c) 2010 Elsevier B.V. All rights reserved.