期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 210, 期 1-2, 页码 73-79出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.02.012
关键词
Amyotrophic lateral sclerosis (ALS); Motor neuron disease; Immunologic alteration; T lymphocyte; Regulatory T cell
资金
- Vialli-Mauro Foundation for research and sport
- Ministero della Salute, Ricerca Finalizzata
In this work we show that patients with sporadic amyotrophic lateral sclerosis exhibit immunological alterations in their blood, with respect to healthy controls, such as: i) increased levels of CD4+ cells and decreased levels of CD8+ T lymphocytes, the latter due to the reduced expression of the anti-apoptotic molecule Bcl-2; ii) significantly reduced CD4+CD25+ regulatory T (Treg) cells and monocytes (CD14+) levels in patients at a less severe stage of disease, suggesting their early recruitment towards the CNS area of primary neurodegeneration; iii) reduced expression of HLA-DR and CCR2 expression, as markers of activation, in monocytes. Since resident microglia partially derives from circulating activated monocytes and Treg cells are known to interact with the local microglia, this study strengthens the hypothesis of an involvement of the adaptive immune system associated with a neuroinflammatory process in the pathobiology of ALS. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据