期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 207, 期 1-2, 页码 45-56出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.11.009
关键词
Systemic Lupus Erythematosus; Neuropsychiatric lupus; Anti-DNA antibodies; Depression
资金
- NIAMS NIH HHS [R56 AR048692, R56 AR048692-06A1] Funding Source: Medline
Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs. (C) 2008 Elsevier B.V. All rights reserved.
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