期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 216, 期 1-2, 页码 113-117出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.06.011
关键词
Multiple sclerosis; Glatiramer acetate; Regulatory T-cells
资金
- TEVA Pharma GmbH
- Gemeinnutzige Hertie-Stiftung [1.319.110/01/11, 1.01.1/04/003]
- Faculty of Medicine, University of Heidelberg
- Federal Ministry of Education and Research [FKZ 01G10905 - 0913]
Naturally occurring regulatory T-cells (Treg) exhibit impaired function in patients with relapsing-remitting multiple sclerosis (RRMS) resulting from an age-inappropriate disproportion between prevalences of newly generated CD31-coexpressing naive Treg and long-lived memory Treg in the periphery. Recent evidence suggests that the immunomodulatory action of glatiramer acetate (CA) includes effects on Treg function and frequencies. We prospectively assessed suppressive activities and frequencies of Treg and Treg subsets in 15 patients with RRMS undergoing long-term therapy with GA. Treatment for up to six months reconstituted naive Treg and increased total Treg numbers with concomitant reversion of the Treg defect. (C) 2009 Elsevier B.V. All rights reserved.
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