期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 212, 期 1-2, 页码 74-81出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.05.002
关键词
Remyelination; Embryonic stem cell; Oligodendrocyte; Multiple sclerosis; Virus
Human embryonic stem cell-derived oligodendrocyte progenitors (OPCs) were transplanted into mice persistently infected with the neurotropic JHM strain of mouse hepatitis virus with established demyelination. Engrafted cells did not survive past 2 weeks following transplantation despite treatment with high dose cyclosporine A. While T cell infiltration into the CNS was dampened, elevated numbers of macrophage/microglia and endogenous OPCs were evident surrounding the implantation site and this was associated with increased remyelination. These data suggest that remyelination was initiated by the local response to xenograft transplantation. These findings illustrate the complexities of OPC transplantation into areas of robust immune-mediated pathology. Published by Elsevier B.V.
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