期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 212, 期 1-2, 页码 35-43出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.04.016
关键词
Hypoxia-ischemia; Microglia; P2X(4) receptor; Minocycline
资金
- Royal Brisbane Women's Hospital Research Foundation
- Lions Medical Research Foundation
In a preterm hypoxia-ischemia model in the post-natal day 3 rat, we characterized how the expression of purine ionotropic P2X(4) receptors change in the brain post-insult. After hypoxia-ischemia, P2X(4) receptor expression increased significantly and was associated with a late increase in ionised calcium binding adapter molecule-1 protein expression indicative of microglia cell activation. Minocycline, a potent inhibitor of microglia, attenuated the hypoxia-ischemia-induced increase in P2X(4) receptor expression. We postulate that P2X(4) receptor-positive microglia may represent a population of secondary injury-induced activated microglia. Future studies will determine whether this population contributes to the progression of injury in the immature brain. (C) 2009 Elsevier B.V. All rights reserved.
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