期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 211, 期 1-2, 页码 105-109出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.03.010
关键词
Multiple sclerosis; Fine mapping; Susceptibility gene; IL2RA
资金
- NHMRC
- Charity Works
- National Center for Research Resources [U54 RR020278]
Multiple sclerosis (MS) is a genetically complex autoimmune disease. To dissect further the involvement of four recent identified MS susceptibility genes (KIAA0350, IL2RA, RPL5 and CD58) in disease pathogenesis, we genotyped 94 haplotype-tagging single nucleotide polymorphisms (SNPs) from these loci in 1146 MS cases and 1309 controls. Seven newly-typed SNP variants were nominally associated with risk of MS, and one SNP (rs791589) in the first intron of the IL2RA gene remained associated after adjustment for rs2104286 genotype, a previously reported SNP association. These data provide further evidence of allelic heterogeneity at the IL2RA locus and point to the existence of at least two independent MS susceptibility alleles. (C) 2009 Elsevier B.V. All rights reserved.
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