期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 213, 期 1-2, 页码 131-134出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.05.013
关键词
MS; Autoimmunity; NADPH oxidase; Reactive oxygen species; Phagocytes
资金
- Research Foundation of the Gothenburg Multiple Sclerosis Society
- Swedish Medical Research Council
- Swedish Association
- Inga-Britt and Arne Lundberg Research Foundation
- Torsten and Ragnar Soderberg Foundation
- Anna-Lisa and Bror Bjornsson Foundation, Gothenburg, Sweden
This study investigated the relationship between the formation of NADPH oxidase-dependent oxygen radicals in peripheral blood leukocytes ('respiratory burst') and disease severity in patients with multiple sclerosis (MS). Oxygen radical production was induced by formyl-Met-Leu-Phe (fMLF) Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM) or phorbol myristate acetate (PMA) and was assessed by quantifying superoxide anion, i.e. the initial radical formed by the NADPH oxidase. Disease severity was evaluated using the Multiple Sclerosis Severity Score (MSSS). In patients with severe disease, the production of superoxide anion was significantly lower for all three inducers of radical formation (p = 0.04-0.004). Our findings are supportive of a protective role of oxygen radicals in autoimmunity. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据