期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 210, 期 1-2, 页码 108-112出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.02.008
关键词
ADAM-17; Multiple sclerosis; Fractalkine; Endothelial cells
ADAM-17 expression is localised to endothelial cells in the human central nervous system (CNS) and is increased in multiple sclerosis (MS) white matter, suggesting a role in MS pathogenesis. Expression of ADAM-17, TIMP-3, and fractalkine were investigated in a human brain endothelial cell line (hCMEC/D3) after pro-inflammatory cytokine treatment. Tumour necrosis factor (TNF) significantly increased fractalkine mRNA (> 100 fold) and protein expression, which was associated with increased shedding of fractalkine from the cell. Fractalkine shedding may regulate immune cell trafficking into the CNS, however, this does not appear to be directly controlled by ADAM-17 activity. (C) 2009 Elsevier B.V. All rights reserved.
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