期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 214, 期 1-2, 页码 78-82出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.06.022
关键词
Lipopolysaccharide; CD200; CD200 receptor; Microglia; Neuroinflammation; Minocycline
资金
- Kuwait University Research Administration [PT01/07]
- Core Research Facility KU [GM01/01, GM01/05]
LPS activates microglia, which are normally maintained in a quiescent state by CD200-CD200 receptor (CD200R) interaction. MAC-1 (a microglia marker) mRNA expression was increased in mice brains up to I year post LPS administration (i.p.). Minocycline treatment did not prevent LPS (5 mg/kg)-induced increase in MAC-1 mRNA but reduced that induced by 0.1 mg/kg LPS. CD200R mRNA decreased starting at 4 h, whereas CD200 mRNA increased at 4 h and decreased at 1 year post LPS inoculation. Thus, LPS-induced changes in CD200-CD200R equilibrium might keep microglia chronically activated. Minocycline does not effectively inhibit microglia activation induced by high-dose LPS. (c) 2009 Elsevier B.V. All rights reserved.
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