期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 201, 期 -, 页码 200-211出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.05.034
关键词
Experimental autoimmune encephalomyelitis; Multiple sclerosis; Remyelination; Gliosis; Axon
资金
- MS Society UK
- Sir David Walker Fund
- Husky Foundation
- MRC (UK)
- National MS Society USA
Multiple sclerosis (MS) represents a considerable challenge to experimentally model due to its twin pathologies of inflammatory demyelination and neurodegeneration along with its multifocal and multiphasic nature. Experimental autoimmune encephalomyelitis ( I EAE) in Biozzi ABH mice has previously been shown to reproduce Many clinical features also found in secondary progressive MS. In this Study we sought to characterise the pathology of chronic EAE in ABH mice. In addition to Marked gliosis, we report Substantial demyelination, remyelination and axonal and neuronal loss, Together with the clinical pattern, Our findings identify chronic EAE as an excellent model of secondary progressive Multiple sclerosis. (c) 2008 Elsevier B.V All rights reserved.
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