期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 195, 期 1-2, 页码 157-163出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.01.005
关键词
neuropathy; neuropathic pain; CRPS; pain intensity; cytokines; cerebrospinal; fluid; soluble tumer necrosis factor receptor; interleukin-1
资金
- NIAID NIH HHS [AI067518] Funding Source: Medline
- NIA NIH HHS [AG20166] Funding Source: Medline
- NIMH NIH HHS [MH61083] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI067518] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH061083] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG020166] Funding Source: NIH RePORTER
This study replicates and extends prior reports of abnormal cytokine levels in chronic pain patients and has correlated the alterations with pain severity. In addition, there appeared to be a need to directly assess cerebrospinal fluid (CSF) because previous findings on cytokine concentrations in peripheral circulation have been inconsistent. CSF and blood specimens were obtained from 14 patients with distal painful non-diabetic polyneuropathy (DPPN) or post-traumatic neuralgia (PTN). Elevated receptor levels for Tumor Necrosis Factor (sTNFr) were the most distinctive abnormality along with low interleukin-10 (IL-10). sTNFr in CSF and blood, and IL-1 ss in CSF, were positively associated with pain intensity, whereas IL-10 in both compartments was inversely correlated with pain symptoms. An imbalance of pro- and anti-inflammatory cytokines appears to be a clinically relevant feature, which may contribute to the maintenance of chronic pain. (C) 2008 Elsevier B.V. All rights reserved.
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