期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 198, 期 1-2, 页码 9-13出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.04.020
关键词
CXCR1/RDC1; CXCR4; CXCL12/SDF-1; chemokine; chemokine receptor
资金
- Helmut Horten Foundation
- Swiss National Science Foundation
- European Community Framework Programme 6-Network of Excellence [LSHG-CT-2003-502935]
CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leukocyte trafficking. Recent findings in zebrafish indicate that a critical activity of the receptor is scavenging of CXCL12 thereby generating guidance cues for CXCR4-dependent migration. The observations do not exclude the possibility that the receptor is capable of inducing signal transduction which is suggestive from Studies of tumor growth and Survival. The pronounced expression in central and peripheral nervous tissue and the absence of a brain phenotype in CXCR7(-/-) mice suggest a Subtle activity of the receptor. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据