期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 196, 期 1-2, 页码 8-15出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.02.004
关键词
experimental allergic encephalomyelitis (EAE); multiple sclerosis (MS); blood-brain barrier (BBB); uric acid (UA); peroxynitrite (ONOO-); cerebellum
资金
- NCCIH NIH HHS [R21 AT001301, AT 0013025, R21 AT001301-01A1] Funding Source: Medline
The blood-brain barrier (BBB) is dramatically but transiently compromised in the cerebella of myelin basic protein immunized mice at least 1 week prior to the development of the paralytic phase of experimental allergic encephalomyelitis (EAE). Treatment of mice with the peroxynitrite-dependent radical scavenger uric acid (UA) during the first week after immunization blocks the early increase in cerebellar BBB permeability and the subsequent development of clinical signs of EAE. These results indicate that the early loss of BBB integrity in the cerebellum is likely to be a necessary step in the development of paralytic EAE. (C) 2008 Elsevier B.V. All rights reserved.
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