期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 200, 期 1-2, 页码 27-40出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.05.019
关键词
EAE; Myelin; Mast cells; Multiple sclerosis
资金
- European Community's Sixth Framework Programme [504926]
- Foundation Foreman Casah Trieste, Italy
A role tor mast cells (MC) in the pathogenesis of multiple sclerosis (MS) has been suggested, based on the analysis of human lesions and on an animal model of the disease (EAE). What role MC play in the development of MS is not well understood. We hypothesized that the link connecting MC with demyelinating diseases may be represented by their interaction with myelin. Here we show that myelin can activate mast cells. This process could be a key event in the mast cell function required for inducing EAE in mice and possibly in MS in man. (c) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据