期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 200, 期 1-2, 页码 71-76出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2008.06.014
关键词
Restraint stress; Mice; Lymphocyte reduction; p53; PI3K; NF-kappa B
资金
- National Institutes of Health (NIH) [DA020120]
- East Tennessee State University Research Development Committee (ETSU RDC) [0048, 07-26M]
Restraint stress, either physical or psychological, can modulate immune function. However, the mechanisms associated with stress-induced lymphocyte reduction remains to be elucidated. We have previously shown that chronic stress induces Fas-mediated lymphocyte reduction. Here, we investigated the mechanisms by which restraint stress modulates lymphocyte reduction. Our data have shown that inhibition of p53 by the p53 inhibitor PFT-alpha attenuates stress-induced reduction in lymphocyte numbers. These results were verified using p53 knockout mice, suggesting a pivotal role of p53 in this process. In addition our data have indicated that PI3K/nuclear factor kappa B (NF-kappa B) signaling pathway plays an important role in the stress-induced lymphocyte reduction. Our study thus demonstrates that restraint stress promotes lymphocyte reduction through p53 and PI3K/NF-kappa B pathways. (c) 2008 Elsevier B.V. All rights reserved.
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