期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 199, 期 1-2, 页码 56-62出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.05.004
关键词
IL-6; IL-10; LPS; skeletal muscle; gastrocnemius
资金
- NIH [RO3 AR049855, R01 AG 023580, RO1 AI 50442]
- USDA [AG 2004-35206-14144]
IL-10 reduces cytokine expression in non-muscle tissues, but its effect on skeletal muscle remains undefined. Therefore, we tested the hypothesis that endogenous IL-10 acts to reduce cytokines in the gastrocnemius muscle by comparing IL-6 and TNF alpha expression in wild-type (IL-10(-/-) and IL-10 deficient (IL-10(-/+) mice fellowship an inflammatory insult induced by peripheral LIPS. IL-6 mRNA expression increased following LPS for both IL-10(-/+) and IL-10 mice; the response was greater and prolonged in IL-10(-/-) mice. Muscle TNF alpha mRNTA also increased, but without differences between genotypes. IL-6 protein concentrations were elevated by LPS with a greater and prolonged response for IL-10(-/-) mice, but TNF alpha did not change. These results provide the first fit vivo evidence that endogenous IL-10 attenuates IL-6 expression by skeletal muscle in response to LPS. (C) 2008 Elsevier B.V. All rights reserved.
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