期刊
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
卷 7, 期 4, 页码 740-749出版社
SPRINGER
DOI: 10.1007/s11481-012-9359-y
关键词
Wnt; Beta-catenin; Glioma; microRNA; Crosstalk
资金
- China National Natural Scientific Fund [30971136, 30872657]
- Tianjin Science and Technology Committee [09JCZDJC17600]
- Program for New Century Excellent Talents in University [NCET-07-0615]
- National High Technology Research and Development Program 863 [2012AA02A508]
Extensive data have shown that Wnt/beta-catenin signaling is associated with various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of Wnt/beta-catenin signaling in glioma, with particular focus on the expression signatures of the main components in Wnt/beta-catenin signaling, the role of key factors in Wnt/beta-catenin signaling, and crosstalk with other signaling pathways. Finally, we discuss the involvement of microRNAs in Wnt/beta-catenin signaling in glioma. This review reveals new insights into the role of Wnt/beta-catenin signaling in gliomagenesis, and highlights new therapeutic approaches for glioma, based on the modulation of the Wnt/beta-catenin pathway.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据