期刊
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
卷 6, 期 3, 页码 420-433出版社
SPRINGER
DOI: 10.1007/s11481-011-9271-x
关键词
Cortical neurons; Primary macrophages; Japanese encephalitis virus; Apoptosis
资金
- Council of Scientific and Industrial Research (CSIR), Govt. of India [27 (1638)/10]
- University Grants Commission, Government of India
Inflammation in the central nervous system (CNS) in Japanese encephalitis (JE) is shown to be the result of microglial activation that leads to the release of various proinflammatory mediators. Peripheral macrophages have been reported to infiltrate into the CNS in JE, though their contribution to the inflammatory process is yet to be elucidated. In this study, using an in vitro macrophage model, we have shown that upon JE virus infection, these cells secrete various soluble factors which may significantly add to the existing inflammatory milieu and lead to apoptotic or necrotic death of neurons. However, it is difficult to quantify the extent of involvement of either the microglia or infiltrating macrophages in the inflammatory processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据