期刊
JOURNAL OF NEUROIMAGING
卷 25, 期 3, 页码 408-414出版社
WILEY
DOI: 10.1111/jon.12137
关键词
Vertebral artery hypoplasia; posterior circulation stroke; ischemic stroke mechanism; duplex ultrasonography
资金
- Framework Programme for Research and Technology Development, Project: Building of Centre of Excellency for Sudden Cerebral Vascular Events, Comenius University Faculty of Medicine in Bratislava [ITMS: 26240120023]
- European Regional Development Fund
BACKGROUNDThe clinical significance of vertebral artery hypoplasia (VAH) and the possible pathomechanism of ischemic stroke in patients with VAH are still not completely clear. METHODSIn a group of 80 posterior circulation strokes (PCS) patients, we compared the location of the ischemic areas in VAH (n = 26) and non-VAH (n = 54) group. We assessed the side of VAH (diameter equal to or less than 2.5mm) with the stroke localization. RESULTSThe possible morphological stroke pathomechanisms in the VAH group - blood flow reorganization (n = 11) and pathway liberation for embolization (n = 10) - were represented equally and may also act together (n = 3). In two cases, the stroke pathomechanism was unknown. The frequency of the presence of conventional risk factors - hypertension (p = 1.0), diabetes mellitus (p = 0.62), hyperlipidemia (p= 1.0) and smoking (p = 1.0) - and the stroke etiology - cardioembolism (p = 0.80), atherosclerotic changes of large (p = 0.76) and small vessels (p = 0.79) - did not differ between the two subgroups. CONCLUSIONIn patients with VAH, the combination of several pathomechanisms of ischemic stroke and the contribution of several risk factors can cause the clinical manifestation of PCS.
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