期刊
JOURNAL OF NEUROCHEMISTRY
卷 129, 期 4, 页码 663-671出版社
WILEY
DOI: 10.1111/jnc.12663
关键词
glutathione; glycolysis; lactate; oxidative stress; pentose-phosphate pathway
资金
- FONDECYT [1100396]
- Ministerio de Economia y Competitividad [SAF2013-41177-R]
- European Regional Development Fund, Instituto de Salud Carlos III (RETICEF) [RD12/0043/0021]
- Junta de Castilla y Leon [SA112A12-2]
- Centro de Microscopia Avanzada CMA BIOBIO [ACT12 PIA]
We proposed that the ascorbic acid (AA) taken up by neurons is rapidly oxidized to dehydroascorbic acid (DHA), which inhibits glycolysis and activates the pentose phosphate pathway (PPP), consequently producing NADPH, a critical antioxidant in the recycling of oxidized glutathione (GSSG). In these metabolic conditions, neurons increase lactate uptake, probably using it as an energy source. This data supported the idea that DHA could play a critical role in the modulation of energy metabolism in neurons.
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