期刊
JOURNAL OF NEUROCHEMISTRY
卷 127, 期 4, 页码 453-460出版社
WILEY
DOI: 10.1111/jnc.12446
关键词
Alzheimer's disease; Drosophila melanogaster; gene regulation; mutagenesis; neurodegenerative diseases; Parkinson's disease
资金
- Bundesministerium fur Bildung und Forschung' ('Nationales Genomforschungsnetz (NGFN+) [01GS08137-5/01GS08137-6a]
- 'Kompetenznetz Degenerative Demenzen' (KNDD) [01GI0703/01GI1005C]
- Alzheimer Forschung Initiative e.V. [12812]
In an aging society, research involving neurodegenerative disorders is of paramount importance. Over the past few years, research on Alzheimer's and Parkinson's diseases has made tremendous progress. Experimental studies, however, rely mostly on transgenic animal models, preferentially using mice. Although experiments on mice have enormous advantages, they also have some inherent limitations, some of which can be overcome by the use of Drosophila melanogaster as an experimental animal. Among the major advantages of using the fly is its small genome, which can also be modified very easily. The fact that its genome lends itself to diverse alterations (e.g. mutagenesis, transposons) has made the fly a useful organism to perform large-scale and genome-wide screening approaches. This has opened up an entirely new field of experimental research aiming to elucidate genetic interactions and screen for modifiers of disease processes in vivo. Here, we provide a brief overview of how flies can be used to analyze molecular mechanisms underlying human neurodegenerative diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据