期刊
JOURNAL OF NEUROCHEMISTRY
卷 122, 期 2, 页码 404-414出版社
WILEY
DOI: 10.1111/j.1471-4159.2012.07769.x
关键词
alpha-synuclein; mitochondria; neurodegeneration; Parkinson's disease
资金
- Research Grants Council of Hong Kong [HIA05/06.SC04, AoE/B-15/01, SBI09/10.SC01]
J. Neurochem. (2012) 122, 404414. Abstract Alpha-synuclein (a-syn) is a synaptic protein that mutations have been linked to Parkinsons disease (PD), a common neurodegenerative disorder that is caused by the degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNc). How a-syn can contribute to neurodegeneration in PD is not conclusive but it is agreed that mutations or excessive accumulation of a-syn can lead to the formation of a-syn oligomers or aggregates that interfere with normal cellular function and contribute to the degeneration of dopaminergic neurons. In this study, we found that a-syn can impair the normal dynamics of mitochondria and this effect is particular prominent in A53T a-syn mutant. In mice expressing A53T a-syn, age-dependent changes in both mitochondrial morphology and proteins that regulate mitochondrial fission and fusion were observed. In the cellular model of PD, we found that a-syn reduces the movement of mitochondria in both SH-SY5Y neuroblastoma and hippocampal neurons. Taken together, our study provides a new mechanism of how a-syn can contribute to PD through the impairment of normal dynamics of mitochondria.
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