期刊
JOURNAL OF NEUROCHEMISTRY
卷 120, 期 -, 页码 3-8出版社
WILEY
DOI: 10.1111/j.1471-4159.2011.07575.x
关键词
Alzheimer's disease; amyloid; APP; genetics; tau
资金
- Medical Research Council [G0701075] Funding Source: Medline
- NIA NIH HHS [P50 AG005681] Funding Source: Medline
- MRC [G0701075] Funding Source: UKRI
- Alzheimers Research UK [ART-PG2010-1, ART-PPG2011A-14] Funding Source: researchfish
- NATIONAL INSTITUTE ON AGING [P50AG005681] Funding Source: NIH RePORTER
In this study, we review our finding of APP mutations in Alzheimers disease in 1990-1991 with the benefit of 20 years perspective. We discuss the historical context in which we made the finding, its immediate and continuing effects on research activity and our hopes for successful clinical testing of the hypothesis. We also briefly discuss the effects finding APP mutations has had on our own careers and those of our colleagues from 1991.
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