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Jordan Tang et al.
AGING-US (2011)
Investigation of alpha-phenylnorstatine and alpha-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors
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Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Design and Synthesis of Potent and Selective BACE-1 Inhibitors
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Design and Synthesis of 5,5′-Disubstituted Aminohydantoins as Potent and Selective Human β-Secretase (BACE1) Inhibitors
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A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates Aβ Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease
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Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
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BIOORGANIC & MEDICINAL CHEMISTRY (2009)
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Design and synthesis of cell potent BACE-1 inhibitors: Structure-activity relationship of P1′ substituents
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Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening
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Evolution of Tertiary Carbinamine BACE-1 Inhibitors: A beta Reduction in Rhesus CSF upon Oral Dosing
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Aminoimidazoles as Potent and Selective Human β-Secretase (BACE1) Inhibitors
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First Demonstration of Cerebrospinal Fluid and Plasma A beta Lowering with Oral Administration of a beta-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
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JOURNAL OF MEDICINAL CHEMISTRY (2008)
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Discovery of isonicotinamide derived β-secretase inhibitors:: In vivo reduction of β-amyloid
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JOURNAL OF MEDICINAL CHEMISTRY (2007)
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JOURNAL OF MEDICINAL CHEMISTRY (2006)
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JOURNAL OF MEDICINAL CHEMISTRY (2006)
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