期刊
JOURNAL OF NEUROCHEMISTRY
卷 116, 期 2, 页码 164-176出版社
WILEY
DOI: 10.1111/j.1471-4159.2010.07109.x
关键词
amphetamine; beta-phenylethylamine; efflux; internalization; methamphetamine; tyramine
资金
- National Institute on Drug Abuse [DA025697]
- National Center for Research Resources [RR00168]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P51RR000168] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K02DA025697] Funding Source: NIH RePORTER
P>It is now recognized that trace amine associated-receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants. Accordingly, research on TAAR1 opens the door to a new avenue of approach for medications development to treat drug addiction as well as the spectrum of neuropsychiatric disorders hallmarked by aberrant regulation of brain monoamines. This overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity.
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