期刊
JOURNAL OF NEUROCHEMISTRY
卷 110, 期 4, 页码 1129-1134出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1471-4159.2009.06181.x
关键词
Alzheimer's disease; amyloid; congophilic angiopathy; dementia; pathogenesis; tau
资金
- MRC [G0701075] Funding Source: UKRI
- Medical Research Council [G0701075] Funding Source: researchfish
- Medical Research Council [G0701075] Funding Source: Medline
The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer's disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid-beta precursor protein (APP) and think how this may relate to the cell death in the disease process.
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