期刊
JOURNAL OF NEUROCHEMISTRY
卷 110, 期 1, 页码 231-243出版社
WILEY
DOI: 10.1111/j.1471-4159.2009.06128.x
关键词
circadian; non-photic; photic; photic-like; serotonin; suprachiasmatic
资金
- Agence Nationale pour la Recherche 'Jeunes Chercheurs/Jeunes Chercheuses' (EC)
- Centre National de la Recherche Scientifique
- French Ministry of National Education and Research
The main mammalian circadian clock, localized in the suprachiasmatic nuclei can be synchronized not only with light, but also with serotonergic activation. Serotonergic agonists and serotonin reuptake inhibitors (e.g., fluoxetine) have a non-photic influence (shifting effects during daytime and attenuation of photic resetting during nighttime) on hamsters' and mice' main clock. Surprisingly, in rats serotonergic modulation of the clock shows essentially photic-like features in vivo (shifting effects during nighttime). To delineate this apparent paradox, we analyzed the effects of fluoxetine and serotonin agonists on rats' clock. First, fluoxetine induced behavioral phase-advances associated with down-regulated expression of the clock genes Per1 and Ror beta and up-regulated expression of Rev-erb alpha during daytime. Moreover, fluoxetine produced an attenuation of light-induced phase-advances in association with altered expression of Per1, Per2 and Ror beta during nighttime. Second, we showed that 5-HT1A receptors-maybe with co-activation of 5-HT7 receptors-were implicated in non-photic effects on the main clock. By contrast, 5-HT3 and 5-HT2C receptors were involved in photic-like effects and, for 5-HT2C subtype only, in potentiation of photic resetting. Thus this study demonstrates that as for other nocturnal rodents, a global activation of the serotonergic system induces non-photic effects in the rats' clock during daytime and nighttime.
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