期刊
JOURNAL OF NEUROCHEMISTRY
卷 106, 期 4, 页码 1493-1502出版社
WILEY
DOI: 10.1111/j.1471-4159.2008.05486.x
关键词
brain; chromatin; histone deacetylase; neuron; oligodendrocyte
资金
- NINDS NIH HHS [R01 NS042925-05A1, R01 NS042925, R01 NS052738, R01 NS042925-06, R01NS052738, R01 NS052738-02, R01NS042925] Funding Source: Medline
The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression depending on the cellular context. YY1 is ubiquitously expressed and highly conserved between species. However, its role varies in diverse cell types and includes proliferation, differentiation, and apoptosis. This review will focus on the function of YY1 in the nervous system including its role in neural development, neuronal function, developmental myelination, and neurological disease. The multiple functions of YY1 in distinct cell types are reviewed and the possible mechanisms underlying the cell specificity for these functions are discussed.
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