期刊
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
卷 14, 期 7, 页码 1319-1328出版社
SPRINGERNATURE
DOI: 10.1039/c4pp00368c
关键词
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资金
- Sao Paulo Research Foundation (FAPESP) [2008/03994-9, 2008/00601-6]
- Centro de Pesquisa em Optica e Fotonica-CEPOF-CEPID [13/07276-1]
- Fundacao para o Desenvolvimento da UNESP-FUNDUNESP-PROINTER [0454/011/14]
This study describes the photoinactivation of Candida albicans in a murine model of oral candidosis, mediated by Photodithazine (R) (PDZ). Six-week-old female Swiss mice were immunosuppressed, and inoculated with C. albicans to induce oral candidosis. After five days, photodynamic inactivation (PDI) mediated by PDZ at concentrations of 75, 100, 125 and 150 mg L-1 was applied on the tongue of mice. Next, microbiological evaluation was performed by recovering C. albicans from the tongue via colony forming units (CFU mL(-1)). After 24 h of treatment, the animals were killed and the tongues were surgically removed for histological analysis. PDI was effective in reducing C. albicans on the tongue of mice using 100 mg L-1 of PDZ, when compared to the positive control group (without treatment). No adverse effect on the tongue tissue was verified after PDI. Therefore, PDI was effective for inactivation of C. albicans without causing any harmful effects on host tissues, which is promising for future clinical trials.
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