期刊
JOURNAL OF NEURO-ONCOLOGY
卷 117, 期 2, 页码 205-215出版社
SPRINGER
DOI: 10.1007/s11060-014-1382-9
关键词
Akt; Human malignant glioma; Resistance to treatment
资金
- Ligue Nationale Contre le Cancer (Comite du Puy De Dome)
- Institut National du Cancer
- Region Auvergne
- Ministere des Enseignements Secondaire et Superieur, Burkina Faso
Gathering evidence has revealed that Akt signaling pathway plays an important role in glioma progression and aggressiveness. Among Akt kinases the most studied, Akt1, has been involved in many cellular processes that are in favor of cell malignancy. More recently, the actions of the two other isoforms, Akt2 and Akt3 have emerged in glioma. After a description of Akt pathway activation, we will explore the role of each isoform in malignant glioma that strengthens the current preclinical and clinical studies evaluating the impact of Akt pathway targeting in glioblastomas.
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