期刊
JOURNAL OF NEURO-ONCOLOGY
卷 113, 期 1, 页码 1-11出版社
SPRINGER
DOI: 10.1007/s11060-013-1084-8
关键词
Biomarkers; Intracellular trafficking; Membrane budding; Tetraspanin; Multi-vesicular bodies (MVB); Tumor microenvironment; Cancer
资金
- NCATS NIH HHS [UH2 TR000931, UH3 TR000931] Funding Source: Medline
Recent studies suggest both normal and cancerous cells secrete vesicles into the extracellular space. These extracellular vesicles (EVs) contain materials that mirror the genetic and proteomic content of the secreting cell. The identification of cancer-specific material in EVs isolated from the biofluids (e.g., serum, cerebrospinal fluid, urine) of cancer patients suggests EVs as an attractive platform for biomarker development. It is important to recognize that the EVs derived from clinical samples are likely highly heterogeneous in make-up and arose from diverse sets of biologic processes. This article aims to review the biologic processes that give rise to various types of EVs, including exosomes, microvesicles, retrovirus like particles, and apoptotic bodies. Clinical pertinence of these EVs to neuro-oncology will also be discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据