期刊
JOURNAL OF NEURAL TRANSMISSION
卷 121, 期 3, 页码 283-287出版社
SPRINGER WIEN
DOI: 10.1007/s00702-013-1106-x
关键词
Alzheimer's disease; Polymorphism; TMEM106B; Risk factor; Association study
资金
- National Natural Science Foundation of China [81000544, 81171209, 81371406]
Recent large genome-wide association studies have found variants in TMEM106B (top SNP rs1990622) as a strong risk factor for frontotemporal lobar degeneration. Moreover, the TMEM106B risk variant is also implicated in the pathologic presentation of Alzheimer's disease (AD). Here, we evaluated the association between TMEM106B rs1990622 polymorphism and late-onset AD (LOAD) in a Northern Han Chinese population consists of 1,133 LOAD patients and 1,159 controls. Our data demonstrate that TMEM106B and APOE interact to increase AD risk.
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