期刊
JOURNAL OF NEURAL TRANSMISSION
卷 117, 期 12, 页码 1419-1422出版社
SPRINGER WIEN
DOI: 10.1007/s00702-010-0523-3
关键词
IRBS; Insulin; Fatty acid; Sporadic Alzheimer's disease
An insulin-resistant brain state (IRBS) was induced by intracerebroventricular application of the diabetogenic substance streptozotocin (STZ) to investigate changes in cerebral fatty acids. Six weeks after the first STZ injection, increases were found in the concentrations of palmitic and stearic acid in temporal cortex; and of palmitic acid in entorhinal cortex indicative of membrane phospholipid breakdown, and damage of the membrane structure. The relevance of these changes is discussed in relation to sporadic Alzheimer's disease.
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