期刊
JOURNAL OF NEURAL TRANSMISSION
卷 117, 期 5, 页码 599-604出版社
SPRINGER WIEN
DOI: 10.1007/s00702-010-0397-4
关键词
Caenorhabditis elegans; DJ-1; Innate immunity; Parkinson's disease; p38(MAPK) pathway
资金
- German Ministry of Education and Research (BMBF) National Genome Research Network (NGFNplus)
- Hertie Foundation
DJ-1 is a neuroprotective gene mutated in recessive Parkinson's disease (PD). In addition to direct protective functions in neurons, DJ-1 regulates neuroinflammatory signaling in primary mouse brain astrocytes. To assess the influence of DJ-1 on innate immunity signaling in vivo, we have generated djr-1 knockout Caenorhabditis elegans. When grown on pathogenic gram-negative bacteria, djr-1 (-/-) worms showed stronger phosphorylation of p38 mitogen-activated protein kinase (PMK-1) and hyper-induction of PMK-1 target genes. Thus, PD-associated DJ-1 contributes to regulation of innate immunity.
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