期刊
JOURNAL OF NEURAL TRANSMISSION
卷 116, 期 3, 页码 275-289出版社
SPRINGER WIEN
DOI: 10.1007/s00702-008-0156-y
关键词
Schizophrenia; Proteomics; Anterior temporal lobe; ICPL; Oligodendrocytes; Myelin; Calcium; Biomarker
资金
- ABADHS (Associacao Beneficente Alzira Denise Hertzog da Silva)
- FAPESP (Fundacao de Amparo Pesquisa do Estado de Sao Paulo)
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- DAAD (Deutscher Akademischer Austauschdienst) and MPG (Max Planck Gesellschaft)
Global proteomic analysis of post-mortem anterior temporal lobe samples from schizophrenia patients and non-schizophrenia individuals was performed using stable isotope labeling and shotgun proteomics. Our analysis resulted in the identification of 479 proteins, 37 of which showed statistically significant differential expression. Pathways affected by differential protein expression include transport, signal transduction, energy pathways, cell growth and maintenance and protein metabolism. The collection of protein alterations identified here reinforces the importance of myelin/oligodendrocyte and calcium homeostasis in schizophrenia, and reveals a number of new potential markers that may contribute to the understanding of the pathogenesis of this complex disease.
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