期刊
JOURNAL OF NEURAL TRANSMISSION
卷 115, 期 9, 页码 1275-1277出版社
SPRINGER WIEN
DOI: 10.1007/s00702-008-0065-0
关键词
early-onset Parkinson's disease; LRRK2 Gly2385Arg mutation; Chinese
The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age <= 45 years) Parkinson's disease was identified and compared with late-onset patients (age > 50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.
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