期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 370, 期 1676, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2014.0237
关键词
B-cell memory; immunoglobulin repertoire; ageing; subclass of antibody
类别
资金
- Human Frontiers Science Programme [RGP9/2007]
- BBSRC [BB/G017190/1]
- Research into Ageing [323]
- Rosetrees Trust
- BBSRC [BB/G017190/1] Funding Source: UKRI
- MRC [MR/L01257X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [886421] Funding Source: researchfish
- Medical Research Council [MR/L01257X/1] Funding Source: researchfish
Older people are more susceptible to infection, less responsive to vaccination and have a more inflammatory immune environment. Using spectratype analysis, we have previously shown that the B-cell repertoire of older people shows evidence of inappropriate clonal expansions in the absence of challenge, and that this loss of B-cell diversity correlates with poor health. Studies on response to vaccination, using both spectratyping and high-throughput sequencing of the repertoire, indicate that older responses to challenge are lacking in magnitude and/or delayed significantly. Also that some of the biologically significant differences may be in different classes of antibody. We have also previously shown that normal young B-cell repertoires can vary between different phenotypic subsets of B cells. In this paper, we present an analysis of immunoglobulin repertoire in different subclasses of antibody in five different populations of B cell, and show how the repertoire in these different groups changes with age. Although some age-related repertoire differences occur in naive cells, before exogenous antigen exposure, we see indications that there is a general dysregulation of the selective forces that shape memory B-cell populations in older people.
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