期刊
JOURNAL OF NEURAL TRANSMISSION
卷 115, 期 12, 页码 1621-1628出版社
SPRINGER WIEN
DOI: 10.1007/s00702-008-0115-7
关键词
Zinc chronic mild stress; BDNF depression
资金
- MNiSW [2 P05A 0178 29]
Zinc exhibits antidepressant-like activity in preclinical tests (the forced swim test and tail suspension test) and in olfactory bulbectomy and chronic unpredictable stress; two models of depression. Zinc also enhances the treatment of depression in humans. In the present study we evaluated the antidepressant activity of zinc in another model of depression-chronic mild stress (CMS) and the effect of zinc treatment on BDNF protein and the mRNA level. In CMS zinc hydroaspartate (10 mg/kg) exhibited a rapid (after 1 week of treatment) antidepressant-like effect. Chronic treatment with zinc induced a 17-39% increase in the BDNF mRNA and protein level in the hippocampus. These data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc in the regulation of BDNF.
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