期刊
JOURNAL OF NEURAL TRANSMISSION
卷 116, 期 8, 页码 983-987出版社
SPRINGER WIEN
DOI: 10.1007/s00702-008-0148-y
关键词
GPCR; Heteromer; Trimer; Oligomer; Neurotransmission; Metabotropic receptors; Heteromer fingerprint
Metabotropic receptors for neurotransmitters on the plasma membrane of neurons are forming homo- hetero- dimers and even homo- or hetero-oligomers. Neurotransmission has been studied assuming that these G-protein-coupled receptors were monomers. Then, on considering receptor dimers, we are entering a new era for the understanding how neurotransmitter receptors decode signals originating at the nervous system. At the moment it is becoming clear that receptor homo and hetero-oligomers provide signaling diversity, help to understand synaptic plasticity and open new therapeutic potential as targets for neurodegenerative and neuropsychiatric diseases.
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