期刊
JOURNAL OF NEURAL ENGINEERING
卷 11, 期 4, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1741-2560/11/4/046005
关键词
closed-loop operation; real-time monitoring; online signal processing; optogenetics; neural stimulation
资金
- FP7 ENLIGHTENMENT project [284801]
- Future and Emerging Technologies (FET) programme within the Seventh Framework Programme for Research of the European Commission
Objective. Closed-loop operation of neuro-electronic systems is desirable for both scientific and clinical (neuroprosthesis) applications. Integrating optical stimulation with recording capability further enhances the selectivity of neural stimulation. We have developed a system enabling the local delivery of optical stimuli and the simultaneous electrical measuring of the neural activities in a closed-loop approach. Approach. The signal analysis is performed online through the implementation of a template matching algorithm. The system performance is demonstrated with the recorded data and in awake rats. Main results. Specifically, the neural activities are simultaneously recorded, detected, classified online (through spike sorting) from 32 channels, and used to trigger a light emitting diode light source using generated TTL signals. Significance. A total processing time of 8 ms is achieved, suitable for optogenetic studies of brain mechanisms online.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据