期刊
JOURNAL OF NEURAL ENGINEERING
卷 11, 期 2, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1741-2560/11/2/026008
关键词
epiretinal; subretinal; intraretinal stimulation; retinal prostheses; stimulation selectivity
资金
- NIH [R01EY018608]
- Stanford University Bio-X Research grant
- Air Force Office of Scientific Research grant [FA9550-10-1-0503]
Objective. Intra-retinal placement of stimulating electrodes can provide close and stable proximity to target neurons. We assessed improvement in stimulation thresholds and selectivity of the direct and network-mediated retinal stimulation with intraretinal electrodes, compared to epiretinal and subretinal placements. Approach. Stimulation thresholds of the retinal ganglion cells (RGCs) in wild-type rat retina were measured using the patch-clamp technique. Direct and network-mediated responses were discriminated using various synaptic blockers. Main results. Three types of RGC responses were identified: short latency (SL, tau < 5 ms) originating in RGCs, medium latency (ML, 3 < t < 70 ms) originating in the inner nuclear layer and long latency (LL, tau > 40 ms) originating in photoreceptors. Cathodic epiretinal stimulation exhibited the lowest threshold for direct RGC response and the highest direct selectivity (network/direct thresholds ratio), exceeding a factor of 3 with pulse durations below 0.5 ms. For network-mediated stimulation, the lowest threshold was obtained with anodic pulses in OPL position, and its network selectivity (direct/network thresholds ratio) increased with pulse duration, exceeding a factor of 4 at 10 ms. Latency of all three types of responses decreased with increasing strength of the stimulus. Significance. These results define the optimal range of pulse durations, pulse polarities and electrode placement for the retinal prostheses aiming at direct or network-mediated stimulation of RGCs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据