期刊
JOURNAL OF NEURAL ENGINEERING
卷 12, 期 1, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1741-2560/12/1/011001
关键词
intracortical microelectrodes; brain machine interfaces; neuro-inflammatory response; neurodegeneration; biocompatibility
资金
- Adolphe Merkle Foundation
- Swiss National Science Foundation (Weder, NRP 62: Smart Materials) [406240_126046]
- Department of Veterans Affairs (Capadona, Rehabilitation Research and Development) [B7122R, B1495-R]
- Presidential Early Career Award for Scientist and Engineers (Capadona, Rehabilitation Research and Development: PECASE)
- Nation Institute of Health (Capadona, National Institute of Neurological Disorders and Stroke) [1R01NS082404-01A1]
To ensure long-term consistent neural recordings, next-generation intracortical microelectrodes are being developed with an increased emphasis on reducing the neuro-inflammatory response. The increased emphasis stems from the improved understanding of the multifaceted role that inflammation may play in disrupting both biologic and abiologic components of the overall neural interface circuit. To combat neuro-inflammation and improve recording quality, the field is actively progressing from traditional inorganic materials towards approaches that either minimizes the microelectrode footprint or that incorporate compliant materials, bioactive molecules, conducting polymers or nanomaterials. However, the immune-privileged cortical tissue introduces an added complexity compared to other biomedical applications that remains to be fully understood. This review provides a comprehensive reflection on the current understanding of the key failure modes that may impact intracortical microelectrode performance. In addition, a detailed overview of the current status of various materials-based approaches that have gained interest for neural interfacing applications is presented, and key challenges that remain to be overcome are discussed. Finally, we present our vision on the future directions of materials-based treatments to improve intracortical microelectrodes for neural interfacing.
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