期刊
JOURNAL OF NERVOUS AND MENTAL DISEASE
卷 199, 期 12, 页码 987-988出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/NMD.0b013e3182392d7e
关键词
Catatonia; schizophrenia; risperidone; refractory; lorazepam
资金
- Astra Zeneca
- Merck/Bristol Myers Squibb
The DSM-IV recognizes catatonia as a subtype of schizophrenia characterized by at least two of the following: motor immobility, excessive motor activity not influenced by external stimuli, and peculiarities of voluntary movement. Catatonia may also occur secondary to mania, depression, or a general medical condition including encephalitis, focal neurological lesions, metabolic disturbances, and drug intoxications and withdrawals. Benzodiazepines remain the first line of treatment; up to 80% of patients respond promptly to Lorazepam challenge; failure to respond to lorazepam may be followed by electroconvulsive therapy. Atypical antipsychotics may be a new alternative in the treatment of catatonia. Successful reduction of the catatonic symptoms has been demonstrated with atypical antipsychotics. A possible mechanism of action for the efficacy of this class of drugs involves the antagonism of the 5-HT2A receptor. We are now reporting a case of treatment response to risperidone in a patient with chronic catatonia resistant to benzodiazepines.
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