期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 370, 期 1671, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2014.0138
关键词
infectious disease; vaccine; immunology; vaccinology; immunization
类别
资金
- MRC [MC_UP_A900_1122, MC_EX_MR/K011944/1, MR/K010174/1] Funding Source: UKRI
- Medical Research Council [MR/K010174/1, MC_EX_MR/K011944/1, MC_UP_A900_1122] Funding Source: Medline
- Department of Health [SRF-2009-02-07] Funding Source: Medline
- Medical Research Council [MR/K010174/1, MR/K010174/1B, MC_EX_MR/K011944/1, MC_UP_A900_1122] Funding Source: researchfish
- National Institute for Health Research [SRF-2009-02-07] Funding Source: researchfish
The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue reviews the performance of vaccines in challenging environments, summarizes current thinking on the reasons why vaccines underperform and considers what approaches are necessary to understand the heterogeneity in responses and to improve vaccine immunogenicity and efficacy.
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