期刊
JOURNAL OF NATURAL PRODUCTS
卷 81, 期 9, 页码 2106-2110出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00261
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan (JSPS KAKENHI) [JP16H06443, JP18H02120]
- JST/NSFC Strategic International Collaborative Research Program
- JSPS Research Fellowships for Young Scientists
The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.
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