期刊
JOURNAL OF NATURAL PRODUCTS
卷 81, 期 8, 页码 1745-1751出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00103
关键词
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资金
- National Natural Science Foundation of China [41506157, 31570032]
- NSFC-Shandong Joint Foundation [U1706206, U1406403]
Two new staurosporine derivatives, staurosporines M1 and M2 (4 and 5), in addition to five previously reported metabolites (1-3, 6, and 7), were generated by the heterologous expression of engineered spc gene clusters in Streptomyces coelicolor M1146. The structures of these derivatives were determined by a combination of spectroscopic methods and CD measurement. Compounds 1, 2, 4, and 5 showed effective activities against three tumor cell lines (HCT-116, K562, and Huh 7.5), and 3 was active against HCT-116 and K562 cells. In addition, compounds 3 and 5 showed undetectable toxicity up to 100 mu M toward the normal hepatic cell line LO2. Based on the IC50 values, their structure and activity relationships are discussed.
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