期刊
JOURNAL OF NATURAL PRODUCTS
卷 77, 期 3, 页码 503-508出版社
AMER CHEMICAL SOC
DOI: 10.1021/np400778m
关键词
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资金
- Austrian Federal Ministry for Science and Research via the OeAD
- Austrian Science Fund (FWF) [P23317, S10703, S10704]
- Herzfelder'sche Familienstiftung
- Ph.D. program BioProMoTion
- University of Vienna
- Austrian Science Fund (FWF) [P 23317] Funding Source: researchfish
- Austrian Science Fund (FWF) [P23317] Funding Source: Austrian Science Fund (FWF)
Activation of nuclear factor-erythroid 2-related factor 2 (Nrf2) contributes to several beneficial bioactivities of natural products, including induction of an increased cellular stress resistance and prevention or resolution of inflammation. In this study, the potential of a crude leaf extract of Chromolaena odorata, traditionally used against inflammation and skin lesions, was examined for Nrf2 activation. Guided by an Nrf2-dependent luciferase reporter gene assay, the phytoprostane chromomoric acid C-I (1) was identified as a potent Nrf2 activator from C. odorata with a CD (concentration doubling the response of vehicle-treated cells) of 5.2 mu M. When tested at 1-10 mu M, 1 was able to induce the endogenous Nrf2 target gene heme oxygenase 1 (HO-1) in fibroblasts. Between 2 and 5 mu M, compound 1 induced HO-1 in vascular smooth muscle cells (VSMC) and inhibited their proliferation in a HO-1-dependent manner, without eliciting signs of cytotoxicity.
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